How To Calculate Coefficients In Chemistry. 0a + 2b + 0c = 2. The partition coefficient of a drug may be determined by shaking it with equal parts of two immiscible solvents (the organic layer, which is saturated with water, and the aqueous drug solution) until equilibrium is attained.

In this example, the equation can be written as follows. The coefficients of the molecular orbitals are calculated by solving the system of equations and the normalization condition given in the following slides. For k = 1, there are equal concentrations of the dye in the two phases;